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Proteins are the most multifaceted macromolecules in living systems and have various useful application in the industry. However, the protein evolves to adapt the natural moderate environment, but the rigorous condition in vitro. And not every protein could be easily expressed in the expression host. Therefore, it is important to design and improve the expression in the host and stability in the rigorous environment. The platform PirD, Protein Improvement and Rational Design, mainly focus on the methods in protein engineering.
- Mining the functional genes from the database.
- Construction of the computational tools to simulate the protein expression, stability and function.
- Design the mutations to improve the protein applicational properties.
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